Toffacitinib Intermediat (2R, 3R) -2,3-BIS [(4-DRASURTHYL) OXY)

Peb cov tshuaj Tofacit Intermediates yog qhov tseem ceeb hauv kev tsim khoom ntawm tofacitinib, cov tshuaj paub zoo siv los kho qee yam kev mob caj dab. Cov Intermediate ua lub luag haujlwm tseem ceeb hauv kev tsim cov toffacitinib, pab txhawb rau nws cov hauj lwm zoo thiab kev ua tau zoo. Ntawm (2R, 3R) -2,3-bis [(4-mthylbeninoyl) oxy acc, 4-silethyl -

Cov qauv molecular thiab qhov hnyav ntawm peb cov Toffacitinib Intermediate qhia nws txoj kev coj dawb huv thiab potency, ua rau muaj kev txhim kho kom haum rau cov tshuaj lag luam. Nrog nws ua tib zoo ntsuas cov khoom xyaw, qhov nruab nrab hauv nruab nrab no tau lees tias muaj kev sib xws thiab ua tau zoo thiab ua tau zoo ntawm cov khoom kawg, toffacitinib. Nws cov molecular cov khoom tseem ua rau toffacitinib's tag nrho cov ruaj khov thiab txee lub neej, kom tau zoo thiab txhim khu kev qha ntawm lub sijhawm ntev.