Tofacitinib intermediate (2r, 3r) -2-bis [(4-methylbenzoyl) oxer]

Tofocitinib yedu inondidaro inokoshesesa mukugadzira maitiro eTofacitinib, mushonga unozivikanwa wakashandiswa kubata mamwe marudzi eArthritis. Iyi yepakati inotsigira yakakosha basa mukugadzirwa kweTofacitinib, inopa mukubudirira kwayo uye kunaka. Via (2r, 3r) -2-Bis

Iyo molecular formula uye uremu hwe yedu tofacitinib yepakati inoratidza kuchena kwayo uye potency, ichiita kuti ive chikamu chakavimbika chechiitiko chechechi yekugadzira. Nezvinyorwa zvaro zvakanyatsorerwa, uyu wepakati anovimbisa kusarudzika uye kushanda kwechigadzirwa chekupedzisira, tofcanitinib. Zvivakwa zvaro zvinopawo kugadzikana kwaTofacitinib zvakawandisa uye hupenyu hwesherufu, chichiita kuti zvinoramba zvichishanda uye zvakavimbika pane kwenguva yakareba.