Khetha rona
JDK e na le lisebelisoa tsa tlhahiso ea sehlopha sa pele le lisebelisoa tsa taolo ea boleng, tse tiisetsang phepelo e tsitsang ea ai e tukang. Sehlopha sa litsebi se tiisitse r & d tsa sehlahisoa. Ka bobeli re batla CMO le CDMO ka 'marakeng oa lapeng le oa machabeng.
Tlhaloso ea Sehlahisoa
N-acetyl-3- (3,5-difluorophenyl)-alanine, kapa u le Acetyl-3-DL-DLIVITIVE EGINO ATRIVILIMANE. E kopanya Acetyl, Alanine le mehele ea mehele e etsang. Sebopeho sena se ikhethang se nang le sona se e fa thepa e ikhethang, e ipitsang sesebelisoa sa bohlokoa ho lamasmacEetical le ba lik'hemik'hale.
E 'ngoe ea litšobotsi tse khethollang tsa N-Acetyl-3-DL-DL-DL-DL-Elena Ke bokhoni ba eona ba ho thibela li-enzyme tse khethehileng' meleng oa motho. Mokhoa ona o ka ama se boleloang ke meriana, haholo nts'etsopele ea mekhoa e mecha ea mekhoa e mecha ea mafu e anngoeng ke enzyme e kentsoeng. Ntle le moo, bokhoni ba eona ba ho fetola lits'ebetso tse ling tsa likokoana-hloko ka ho sebelisana 'moho le li-receptisteng tse ikhethileng li etsa hore e be letlotlo la bohlokoa thutong ea litsela tsa' nete.
Karolo e 'ngoe e susumetsang ea komporo ena ke ka lebaka la bokhoni ba eona e le thibelo ea moaho bakeng sa li-molecales tse ling tse rarahaneng. Ho feto-fetoha ha eona ho lumella ho theoa ha mekhatlo e mecha ea lik'hemik'hale, e etsa hore e be thuso haholo ho chemistri ea bongaka le ho sibolla lithethefatsi. Bafuputsi ba ka sebelisa thepa e ikhethang ea N-acetyl-3-dl-Dl-3-dl-DL-Alanine ho theha bakhethoa ba lithethefatsi ba nang le phepelo ea phaello.
Ntle le moo, N-Acetyl-3-DL-DL-Alanine e na le li-solbility tse fapaneng ka liketsong tse fapaneng tsa polar. Boiteko ba eona tlas'a maemo a fapaneng bo etsa hore litholoana e tšepahalang, li lumella bafuputsi ba ho tsamaisa liteko tse phethahetseng 'me ba fumana lintlha tse nepahetseng.
Boea le boleng ba N-Acetyl-3-DL-DL-DL-Elenine li bohlokoa ka ho fetisisa, hape e le mofani ea ikhohomosang, re tiisetsa hore lihlahisoa tsa rona li fumana maemo a rona holimo. N-Acetyl-3-dl-dl-dl-dl-dl-lalenine e ntse e sebelisoa ka theknoloji ea Naha le mehato ea taolo ea boleng bo holimo ho netefatsa sehlopha se seng le se seng.
