I-vorate vorolazan I. 1260121-27-27-27-2

I-vorolazan fimarate isebenza ngokuthintela impompo ye-proton kwisisu, ngaloo ndlela kuncitshiswa imveliso ye-guric acid. Ngokungafaniyo ngokungafaniyo ne-Proton Puitsitors (PPIs), i-vorolazan ibonakalise ngokukhawuleza inyathelo lesenzo kunye nendlela yokugcina unyango, esenza ukuba inyathelo lonyango lwe-acid, esenza ukuba ibe lukhetho olunempumelelo lonyango kwizigulana eziphendulwe kakubi kunyango.

Enye yezona zinto zibalulekileyo ze-vorolazan kukukwazi ukoyisa ukusikelwa umda kwamanye amachiza aphantsi. Indlela yayo eyodwa ithintele i-acid ifihla ngokuguquguqukayo kwaye ixesha elide, ikhokelela kulawulo oluphambili lwempawu kunye nokuthintela isilonda esiphindaphindiweyo. Ukongeza, i-vorolazan cumarate ibonisiwe ukuba ibe negalelo eliphantsi lokudibana kweziyobisi, lenza ukhetho olukhuselekileyo lwezigulana ezinemidlalo emininzi efuna iirejimeni zerejimeni.

Kwizifundo zeklinikhi, i-gorolazan yobonise ukusebenza kakuhle xa kuthelekiswa ne-PPIs ekhoyo, ngokutshintsha kwesenzo kunye nokucinezelwa kwe-acid ephezulu. Oku kuthetha ukuba abaguli banokufumana ukukhululeka ngokukhawuleza kwiimpawu ezifana nokubetha kwentliziyo kunye neRellux, ukuphucula umgangatho wobomi kunye nokunciphisa imfuneko yokuhlangula amayeza.