Inkcazo
I-Palbociclib iphakathi kwi-2-Amino-5-I-CASMPPPPPRIGrine CAS 1072-97-5! Lo mgangatho uphambili kwicandelo eliphakathi licandelo elibalulekileyo kwi-synthesis ye-pulbociclib, i-cyclin exhomekeke kwi-cyclin ene-4 kunye ne-6 inhibitor. Ifomula yemolekyuli yeli candelo le-C5H5BRNR2 kwaye ubunzima bemolekyuli buyi-173.01. Isetyenziselwa ukuveliswa kwe-pulbociclib, ichiza elibalulekileyo ngokuchasene nomhlaza webele.
I-Palbociclib, ikwaziwa ngegama layo lokurhweba, libonwa ngokubanzi ngokusebenza kwalo lokunyanga i-hormone ye-hormone kunye nomhlaza we-stast. Njengecandelo eliphambili kwinkqubo yemveliso yePalbociclib, i-2-Amino-5-i-romopririridine iphakathi sisithako esibalulekileyo kumzi-mveliso wamachiza. Ukucoceka kwayo kakhulu kunye nokubekwa kwekhemikhali echanekileyo kwenza isithako esibalulekileyo ekuvelisweni kwesi siyobisi esonga ubomi.
Sikhethe
I-JDK ingumnikazi wemveliso yokuqala yemveliso kunye nezixhobo zolawulo lomgangatho, eziqinisekisa ukuhanjiswa kwezinto eziphakathi kwe-API. Iqela lobuchule liqinisekisa i-R & D lemveliso. Ukulwa bobabini, sikhangela i-CMO kunye ne-CDM kwimakethi yasekhaya nezamanye amazwe.
