Zikhethele thina
I-JDK ingumnikazi wezindawo zokukhiqiza ezisezingeni lokuqala kanye nezinsizakusebenza zokuphathwa kwekhwalithi, eziqinisekisa ukuhlinzekwa okuzinzile kwemiphakathi ye-API. Iqembu lobuchwepheshe liqinisekisa i-R & D yomkhiqizo. Ngokumelana nakho konke, sifuna i-CMO ne-CDMO emakethe yasekhaya nakwamanye amazwe.
Ukuchazwa Komkhiqizo
Emgogodleni wayo, 17-amino-10-axy-3,8,12,15-tetraoxa-9-azahepladecanoic acid kuyinto eyinkimbinkimbi enamandla amakhulu ezinhlobonhlobo zezicelo. Ukwakheka kwalo kwamangqamuzana kanye nenhlanganisela eyingqayizivele yezakhi kwenza kube yimpahla ebalulekile yokuthuthuka kwezidakamizwa, izinsizakusebenza ze-biochemistry kanye nemizamo yesayensi ehlobene nayo.
Enye yezinto eziphambili zalo mkhiqizo ukuguquguquka kwayo. 17-Amino-10-Oxy-3,6,12,15-tetraoxa-9-azahepladecanoic acid ingasetshenziswa njengebhulokhi yokwakha ekuhlanganiseni kwama-molecule ahlukahlukene we-bikoactive, njenge ama-peptides namaprotheni. Amaqembu awo asebenzayo kanye nokulandelana kwayo kwe-Amino acid anika amandla ukuguqulwa okusebenzayo nokunembile, ukuqinisekisa izinga eliphakeme lokulawula nokucaciswa kokuklanywa kwezidakamizwa.
Abaphenyi kanye nososayensi emkhakheni wezokwelapha kanye nokutholwa kwezidakamizwa bayozuza kakhulu ngokufaka lo mkhiqizo ocwaningweni lwabo. Izicelo ezingaba khona zisukela ezinhlelweni ezihlosiwe zokulethwa kwezidakamizwa ekuthuthukisweni kwama-novel zokwelapha agents. Ngokufaka izakhiwo ezihlukile ze-17-amino-10-oxy-3,6,12,15-tetraoxa-9-azahepladecanoic acid, izinkampani ezenza imithi zingaqala ukusungula futhi zidale ukwelashwa okuhlukahluka kwezifo ezahlukahlukene.
Ngaphezu kwalokho, ukuqina komkhiqizo kuqinisekisa ukuqina nokwethenjwa ngaphansi kwezimo ezahlukahlukene zokuhlola. Isisindo salo molecular kanye nokwakheka kwakhelwe ngokucophelela ukuhlinzeka ngokuhlinzekwa ngokuphelele kwe-solubity, okuvumela ukuhlanganiswa okulula kube amaphrothokholi wokuhlola. Ngaphezu kwalokho, ubumsulwa bomkhiqizo wokuhlanzeka kanye nokuqina kwesiqinisekiso semiphumela esembukayo, okwenza kube yithuluzi elisemqoka lemiphumela yocwaningo ethembekile.
Uma kukhulunywa ngokuphepha, sithatha zonke izinguquko zokuqinisekisa ukuthi i-17-amino-10-axy-3,6,12,15-tetraoxa-9-azaheetadecanoic acid ihlangana namazinga aphezulu kakhulu. Izindlela eziqinile zokulawula ikhwalithi zithathwa kuyo yonke inqubo yokukhiqiza ukuze kuqinisekiswe ukungabikho kokungcola noma ukungcola.
