Zikhethele thina
I-JDK ingumnikazi wezindawo zokukhiqiza ezisezingeni lokuqala kanye nezinsizakusebenza zokuphathwa kwekhwalithi, eziqinisekisa ukuhlinzekwa okuzinzile kwemiphakathi ye-API. Iqembu lobuchwepheshe liqinisekisa i-R & D yomkhiqizo. Ngokumelana nakho konke, sifuna i-CMO ne-CDMO emakethe yasekhaya nakwamanye amazwe.
Ukuchazwa Komkhiqizo
I-Compound, enenombolo ye-HAS ye-146464-90-6, i-compound efunwe kakhulu ngenxa yezakhiwo zayo ezinhle kakhulu nezinhlobonhlobo zezicelo. Ihlanganiswe ngokucophelela kusetshenziswa ubuchwepheshe bezwe ukuqinisekisa ubumsulwa bayo nokusebenza kahle kokuhlolwa okuhlukahlukene kwelebhu. Izinqubo zokukhiqiza ezingemuva ziqinisekisa ikhwalithi ephezulu yomkhiqizo wokugcina futhi zihlangabezane nezidingo eziqinile zocwaningo lwesayensi.
Enye yezinto ezithakazelisa kakhulu kwale nhlanganisela ukusebenza kwayo okuhlukahlukene. Ukuhleleka kwalo kwamangqamuzana kukwenza kusebenzisana nokuxhumana nezinhlanganisela ezahlukahlukene ze-organic, okwenza kube ngumuntu omuhle kakhulu wezinhlelo zokusebenza ezahlukahlukene. Izakhiwo zayo ezihlukile zikwenza kufanelekile ukusetshenziswa njenge-reagent ekucwaningeni okwenziwe ngemithi, ukuhlanganiswa kwe-organic kanye nokuhlaziywa kwamakhemikhali.
Abaphenyi emkhakheni we-pharmacology bazohlomula ngokukhethekile nge-methylty yethu 4- (Methoxycarbonyl) -α-propargyl-phenyliotate. Amandla awo okusebenzisana ngokukhetha ngokukhetha okuqondile okuhlotshezwa ngokwemvelo kubangela amandla amakhulu okuthola izidakamizwa kanye nentuthuko. Ngokubopha le nhlanganisela, ososayensi bazokwazi ukuklama izidakamizwa ezintsha ezibhekise izifo ezithile ngokunembe futhi ngempumelelo.
Emkhakheni wokuhlanganiswa kwe-organic, le mpikiswano inikeza amathuba angapheli. Isakhiwo saso sokusebenza sivumela ukukhiqizwa kwama-molecule ayinkimbinkimbi ezi-organic ngokusebenzisa ukusabela okuhlukahlukene kwamakhemikhali. Ochwepheshe bamakhemikhali bazokwazisa ukusebenza kwayo ekuphendukeni kwe-catalyzing kanye nekhono layo lokwakha ama-Intermedialetes ezinzile, ukwenza lula izinqubo zokwenziwa.
Ngokwengeziwe, i-methyl yethu 4- (Methoxycarbonyl) -α-2-propargyl-phenylacetate inokuqina okuhle nokuphila isikhathi eside, okuvumela ukusetshenziswa kwesikhathi eside ngaphandle kokuyekethisa ubuqotho bayo. Ukusebenza kwalo okuthembekile kuqinisekisa imiphumela engaguquki futhi evuselelwa kabusha, okwandayo ukuthembeka kokuhlola nokwehlisa imfucuza engaba khona.
