Ukufanisa
I-CAS Inombolo 1378865-93-0, i-4-methyl-2- (1,1,1-Trifluoro-2-Dimethyl-2-Ethyl Idlala indima ebalulekile ekusetshenzisweni kwe-alpelisib, ukwelashwa okuhlosiwe kweziguli ezinomdlavuza webele osezingeni eliphezulu noma ama-tumor aqinile agcina izinguquko ze-pik3ca.
Lo medi walemediate usebenza njengendawo yokwakha ye-Alpelisib synthesis, evumela ukukhiqizwa kwezidakamizwa ezikhombisile ukusebenza kahle kwezilingo zezempilo. Ukwakheka okunembile kwamakhemikhali we-Intermediates yethu kuqinisekisa ukuhambisana kwawo kanye nokusebenza ngempumelelo ngesikhathi sokuhlanganiswa, kufaka isandla ekuhlanzeni okuphezulu nasekusebenzeni komkhiqizo wokugcina wezemithi.
I-4-methyl-2- (1,1,1-Trifluoro-2-Dimethyl-2-Ethyl) I-Pyridine Intermedieate iyingxenye esemqoka ekubumbeni kwamakhemikhali kwe-Alpelisib kanye ne-Ukhiye Ephakathi kuyo yonke inqubo yokukhiqiza. Ngefomula yalo eqondile yama-molecular kanye nesisindo, yakhelwe ukufeza izidingo eziqinile zokukhiqiza amakhambi, ukuqinisekisa ukungaguquguquki nokwethenjwa ekukhiqizweni kwe-alpelisib.
Zikhethele thina
I-JDK ingumnikazi wezindawo zokukhiqiza ezisezingeni lokuqala kanye nezinsizakusebenza zokuphathwa kwekhwalithi, eziqinisekisa ukuhlinzekwa okuzinzile kwemiphakathi ye-API. Iqembu lobuchwepheshe liqinisekisa i-R & D yomkhiqizo. Ngokumelana nakho konke, sifuna i-CMO ne-CDMO emakethe yasekhaya nakwamanye amazwe.
