Zikhethele thina
I-JDK ingumnikazi wezindawo zokukhiqiza ezisezingeni lokuqala kanye nezinsizakusebenza zokuphathwa kwekhwalithi, eziqinisekisa ukuhlinzekwa okuzinzile kwemiphakathi ye-API. Iqembu lobuchwepheshe liqinisekisa i-R & D yomkhiqizo. Ngokumelana nakho konke, sifuna i-CMO ne-CDMO emakethe yasekhaya nakwamanye amazwe.
Ukuchazwa Komkhiqizo
I-Ethyl 2-CyanoaceTate iyingxenye ebalulekile yenqubo yokukhiqiza ye-Finerenone esebenza ngempumelelo yokwelapha futhi ingumphakathi oyisihluthulelo ekuhlanganiseni izidakamizwa. Yaziwa ngokusebenza kwayo okuhlukile ekwelapheni isifo sozinso nokuhluleka kwenhliziyo, iFinerenone ithole ukunakwa okugcwele ochwepheshe bezokunakekelwa kwempilo kanye neziguli. Ngakho-ke, ukubaluleka kuka-Ethyl 2-Cyanoacetate akunakweqiwa njengoba kudlala indima ebalulekile ekwenziweni kwalolumuthi oguqula impilo.
Inombolo ye-CAS ye-ETYL 2-Cyanoacetate ingu-65193-87-5. Inezakhiwo ezahlukahlukene ezizuzisayo ezihlukanisa neminye imiphakathi yezemithi. Isakhiwo saso samangqamuzana sinikezela ngokuqina okuhle nokuhambisana nokusabela okuhlukahlukene kwamakhemikhali, kuqinisekisa inqubo yokungenziwa engenamthungo. I-Compound ibuye ibe nobumsulwa obuphezulu, iphinde yandise ukuthembeka kwayo kanye nokusebenza kahle.
Izikhungo zethu zokukhiqiza ezithuthukile nezinyathelo eziqinile zokulawula ikhwalithi ziqinisekisa imikhiqizo esezingeni eliphakeme ehlangabezana nezindinganiso eziqinile zezimboni. Njalo phakathi kwe-Ethyl 2-Cyanoacetate kuthola ukuhlolwa okuqinile ukuze kuqinisekiswe ubumsulwa bawo, i-potency kanye nokuphepha. Siyakuqonda ukubaluleka okubalulekile kokuhlinzeka ngemikhiqizo ethembekile futhi ephephile, ikakhulukazi embonini yezemithi lapho kuhlala khona.
Ngaphezu kokusebenza kwayo okuhle njenge-Finerenone Intermediate, ethyl 2-Cyanoacetate inikeza ukuguquguquka kwezinye izinhlelo. Izakhiwo zayo ezihlukile zamakhemikhali zikwenza kube isithako esibalulekile ekukhiqizweni kwamakhompiyutha ahlukahlukene emithi namakhemikhali amahle. I-Ethyl 2-CyanoaceTate inezinhlobonhlobo zokusetshenziswa okungaba khona, yethula amathuba amaningi okuqamba kanye nentuthuko kwamakhemikhali wezokwelapha.
