I-TOFaciTiniB Intermediate (2r, 3r) -2,3-BIS [(4-Methylbenziyl) I-OxeCinic Acid kanye (3r, 4r) - n, Phenylyl-1- (Phenylmethyl) -3-Piperidine Amine Case No. 477600-71-8

I-TOFAcitinib yethu i-Intermediates yethu ibalulekile kwinqubo yokukhiqiza yeTofacitinib, isidakamizwa esaziwayo esisetshenziselwa ukwelapha izinhlobo ezithile zesifo samathambo. Lo msulwa udlala indima ebalulekile ekukhiqizweni kwe-tofacitiinib, efaka isandla ekusebenzeni kwayo kanye nekhwalithi. I-Via (2r, 3r) -2,3-BIS [(4-Methylbenziyl) I-OxeCinic acid kanye (3r, 4r) - inhlanganisela eqondile ye-3-piperinamines, umkhiqizo wethu uqinisekisa ukuhlanganiswa kwekhwalithi ephezulu ye-tofacitiinib ehlangabezana nayo futhi idlula amazinga emboni.

Ifomula ye-molecular kanye nesisindo se-tofacitinib yethu Imenyezelisi ibonisa ubumsulwa bayo kanye ne-potency yayo, okwenza kube yingxenye ethembekile yenqubo yokukhiqiza yezemithi. Ngezithako zayo ezilinganiswe ngokucophelela, lo mlethelisi uqinisekisa ukungaguquguquki kanye nokusebenza kahle komkhiqizo wokugcina, i-tofacitiinib. Izakhiwo zalo ze-molecular nazo zinomthelela ekuqineni okuphelele kwe-tofacitin