Ukufanisa
I-TopIrastat Intermediate 2-CyanooSisoticotic Acid, CAS No. 161233-97-2. Lo mkhiqizo waziwa nangamanye amagama: 2-CyanopyriDine-4-carboxylic acid, 2-Cyano-4-pyridinecarboxbylayicyylic acid, kanye ne-4-pyridinecarboxylicyylic acid, 2-Cyano-. Ifomula ye-molecular yalesi sihlanganisi esiphakathi yi-C7H4NO2 kanye nesisindo samangqamuzana kungu-148.1189. Kuyingxenye ebalulekile ekuhlanganiseni kwe-Topirastat (isidakamizwa esisetshenziselwa ukwelapha i-hypericemia ezigulini ze-gout).
I-2-Cyanososototicotic acid idlala indima ebalulekile ekwakhiweni kwe-topIrastat, esebenza ngokuvimbela i-Xanthine Oxidase, i-enzyme ebandakanyeka ekukhiqizweni kwe-Uric acid. Ngenxa yalokhu, amazinga e-UIC acid ekunciphiseni kwegazi, ukunciphisa izimpawu zeziguli ze-gout. Lesi sivumelwano esiphakathi isithako esiyisihluthulelo senqubo yokukhiqiza ye-Topirastat, okwenza kube yingxenye ebalulekile yomkhakha wezemithi.
Zikhethele thina
I-JDK ingumnikazi wezindawo zokukhiqiza ezisezingeni lokuqala kanye nezinsizakusebenza zokuphathwa kwekhwalithi, eziqinisekisa ukuhlinzekwa okuzinzile kwemiphakathi ye-API. Iqembu lobuchwepheshe liqinisekisa i-R & D yomkhiqizo. Ngokumelana nakho konke, sifuna i-CMO ne-CDMO emakethe yasekhaya nakwamanye amazwe.
